Congratulations, Ethan!

Ethan Jones’s new preprint, LanTERN: a fluorescent sensor that specifically binds lanthanides, is now available on bioRxiv.

Quincey’s take: Ethan took an in vivo calcium imaging workhorse, GCaMP, and turned it into a biochemical lanthanide sensor we named LanTERN. LanTERN achieves a perfect switch of specificity with pinpointed mutations while also increasing LanTERN’s fluorescent signal vs. its parent GCaMP. The result: we can now “see” protein-lanthanide binding in a straightforward, robust, and extensible way; we can do experiments that we couldn’t do before.

Ethan’s commitment to scientific transparency is evident throughout this manuscript, but particularly in the Supplement, where it is truly remarkable.

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